Interactions among related genes of renin-angiotensin system associated with type 2 diabetes.

ABSTRACT:

Objective

To explore the association between epistasis among related genes of the renin-angiotensin system (RAS) and type 2 diabetes.

Research design and methods

Gene polymorphisms were genotyped in 394 type 2 diabetic patients and 418 healthy control subjects in this case-control study. We used the multifactor dimensionality reduction method to identify gene-gene interactions.

Results

No single locus was associated with type 2 diabetes, except for the insert/deletion (I/D) polymorphism of the ACE gene in female subjects. In multi-locus analyses, in male subjects the model of rs2106809 (ACE2), rs220721 (Mas), rs699 (AGT), and I/D (ACE) was significant (P = 0.043). This combination was associated with a 4.00 times (95% CI 2.51-6.38; P < 0.0001) greater prevalence of ty

SUBMITTER: Yang JK 

PROVIDER: S-EPMC2945173 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature