Ontology highlight
ABSTRACT:
SUBMITTER: Chang MC
PROVIDER: S-EPMC2949072 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Nature neuroscience 20100822 9
Homeostatic synaptic scaling alters the strength of synapses to compensate for prolonged changes in network activity and involves both excitatory and inhibitory neurons. The immediate-early gene Narp (neuronal activity-regulated pentraxin) encodes a secreted synaptic protein that can bind to and induce clustering of AMPA receptors (AMPARs). We found that Narp prominently accumulated at excitatory synapses on parvalbumin-expressing interneurons (PV-INs). Increasing network activity resulted in a ...[more]