Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.

ABSTRACT:

Background & aims

The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continually into 4 principal specialized cell types, yet underlying mechanisms of differentiation are poorly understood. We identified stomach-restricted expression of the forkhead transcription factor FOXQ1.

Methods

We used a combination of genetic, histochemical, ultrastructural, and molecular analysis to study gastric cell lineages with respect to FOXQ1.

Results

Within the developing and adult gastrointestinal tract, Foxq1 messenger RNA (mRNA) is restricted to the stomach and expressed predominantly in foveolar (pit) cells, the abundant mucin-producing cells that line the mucosal s

SUBMITTER: Verzi MP 

PROVIDER: S-EPMC2955860 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature