Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth.

ABSTRACT: The development of multicellular organisms relies on the coordinated control of cell divisions leading to proper patterning and growth. The molecular mechanisms underlying pattern formation, particularly the regulation of formative cell divisions, remain poorly understood. In Arabidopsis, formative divisions generating the root ground tissue are controlled by SHORTROOT (SHR) and SCARECROW (SCR). Here we show, using cell-type-specific transcriptional effects of SHR and SCR combined with data from chromatin immunoprecipitation-based microarray experiments, that SHR regulates the spatiotemporal activation of specific genes involved in cell division. Coincident with the onset of a specific formative division, SHR and SCR directly activate a D-type cyclin; furthermore, altering the expression o

SUBMITTER: Sozzani R 

PROVIDER: S-EPMC2967763 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature