Identification of transcription factor's targets using tissue-specific transcriptomic data in Arabidopsis thaliana.

ABSTRACT:

Background

Transcription factors (TFs) regulate downstream genes in response to environmental stresses in plants. Identification of TF target genes can provide insight on molecular mechanisms of stress response systems, which can lead to practical applications such as engineering crops that thrive in challenging environments. Despite various computational techniques that have been developed for identifying TF targets, it remains a challenge to make best use of available experimental data, especially from time-series transcriptome profiling data, for improving TF target identification.

Results

In this study, we used a novel approach that combined kinetic modelling of gene expression with a statistical meta-analysis to predict targets of 757 TFs using expression data of 14,905

SUBMITTER: Srivastava GP 

PROVIDER: S-EPMC2982689 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature