Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases.

ABSTRACT: Genetic testing for susceptibility to common diseases based on a combination of genetic markers may be needed because the effect size associated with each genetic marker is small. Whether or not a genome profile based on a combination of markers could yield a useful test can be evaluated by assessing the discriminative accuracy. The authors present a simple method to calculate the clinical discriminative accuracy of a genomic profile when the relative risk and genotype frequency of each genotype are known. In addition, the clinical discriminative accuracy of a genetic test is presented for given values of the heritability and prevalence of the disease and for the population-attributable fraction of the combined genetic markers. For given values of relative risk and genotype frequency, the

SUBMITTER: Moonesinghe R 

PROVIDER: S-EPMC2987256 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature