The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation.

ABSTRACT:

Background

Delayed implantation is a developmental arrest at the blastocyst stage and a good model for embryo implantation. MicroRNAs (miRNAs) have been shown to be involved in mouse embryo implantation through regulating uterine gene expression. This study was to have an integrative analysis on global miRNA and mRNA expression in mouse uterus under delayed implantation and activation through Illumina sequencing.

Methodology/principal findings

By deep sequencing and analysis, we found that there are 20 miRNAs up-regulated and 42 miRNAs down-regulated at least 1.2 folds, and 268 genes up-regulated and 295 genes down-regulated at least 2 folds under activation compared to delayed implantation, respectively. Many different forms of editing in mature miRNAs are detected. The per

SUBMITTER: Su RW 

PROVIDER: S-EPMC2993968 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature