Dataset Information

Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.

ABSTRACT:

Rationale

Wood smoke-associated chronic obstructive pulmonary disease (COPD) is common in women in developing countries but has not been adequately described in developed countries.

Objectives

Our objective was to determine whether wood smoke exposure was a risk factor for COPD in a population of smokers in the United States and whether aberrant gene promoter methylation in sputum may modify this association.

Methods

For this cross-sectional study, 1,827 subjects were drawn from the Lovelace Smokers' Cohort, a predominantly female cohort of smokers. Wood smoke exposure was self-reported. Postbronchodilator spirometry was obtained, and COPD outcomes studied included percent predicted FEV?, airflow obstruction, and chronic bronchitis. Effect modification of wood smoke exposure with current cigarette smoke, ethnicity, sex, and promoter methylation of lung cancer-related genes in sputum on COPD outcomes were separately explored. Multivariable logistic and poisson regression models were used for binary and rate-based outcomes, respectively.

Measurements and main results

Self-reported wood smoke exposure was independently associated with a lower percent predicted FEV? (point estimate [± SE] -0.03 ± 0.01) and a higher prevalence of airflow obstruction and chronic bronchitis (odds ratio, 1.96; 95% confidence interval, 1.52-2.52 and 1.64 (95% confidence interval, 1.31-2.06, respectively). These associations were stronger among current cigarette smokers, non-Hispanic whites, and men. Wood smoke exposure interacted in a multiplicative manner with aberrant promoter methylation of the p16 or GATA4 genes on lower percent predicted FEV?.

Conclusions

These studies identify a novel link between wood smoke exposure and gene promoter methylation that synergistically increases the risk for reduced lung function in cigarette smokers.

SUBMITTER: Sood A

PROVIDER: S-EPMC3001253 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.

Sood Akshay A Petersen Hans H Blanchette Christopher M CM Meek Paula P Picchi Maria A MA Belinsky Steven A SA Tesfaigzi Yohannes Y

American journal of respiratory and critical care medicine 20100701 9

<h4>Rationale</h4>Wood smoke-associated chronic obstructive pulmonary disease (COPD) is common in women in developing countries but has not been adequately described in developed countries.<h4>Objectives</h4>Our objective was to determine whether wood smoke exposure was a risk factor for COPD in a population of smokers in the United States and whether aberrant gene promoter methylation in sputum may modify this association.<h4>Methods</h4>For this cross-sectional study, 1,827 subjects were drawn ...[more]

PMID: 20595226

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Dataset Information

Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.

Rationale

Objectives

Methods

Measurements and main results

Conclusions

Publications

Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.

Similar Datasets

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