Ontology highlight
ABSTRACT:
SUBMITTER: Daniel JA
PROVIDER: S-EPMC3008398 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100729 5994
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired trimethylation of histone 3 at lysine 4 (H3K4me3) and transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (I ...[more]