Ontology highlight
ABSTRACT:
SUBMITTER: Vuong BQ
PROVIDER: S-EPMC4005274 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Nature immunology 20131006 11
The ability of activation-induced cytidine deaminase (AID) to efficiently mediate class-switch recombination (CSR) is dependent on its phosphorylation at Ser38; however, the trigger that induces AID phosphorylation and the mechanism by which phosphorylated AID drives CSR have not been elucidated. Here we found that phosphorylation of AID at Ser38 was induced by DNA breaks. Conversely, in the absence of AID phosphorylation, DNA breaks were not efficiently generated at switch (S) regions in the im ...[more]