Targeting NF-κB in infantile hemangioma-derived stem cells reduces VEGF-A expression.

ABSTRACT:

Background

infantile hemangioma (IH) is a most common tumor of infancy. Using infantile hemangioma-derived stem cells (HemSCs), we recently demonstrated that corticosteroids suppress the expression of VEGF-A, monocyte chemoattractant protein-1 (MCP-1), urokinase plasminogen activator receptor (uPAR), and interleukin-6 (IL-6); each of these are known targets of the transcription factor nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB). In the present study, we examined the expression of these NF-κB target genes in IH tissue specimens and the effect of NF-κB regulation on the expression of pro-angiogenic cytokines, and in particular VEGF-A, in HemSCs.

Materials and methods

RNA extracted from IH tissue and hemangioma-derived stem cells (HemSCs) was used to anal

SUBMITTER: Greenberger S 

PROVIDER: S-EPMC3034388 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature