Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNAs, which regulate mRNA translation/decay, and may serve as biomarkers. We characterised the expression of miRNAs in clinically sampled oral and pharyngeal squamous cell carcinoma (OSCC and PSCC) and described the influence of human papilloma virus (HPV).

Methods

Biopsies obtained from 51 patients with OSCC/PSCC and 40 control patients were used for microarray analysis. The results were correlated to clinical data and HPV status. Supervised learning by support vector machines was employed to generate a diagnostic miRNA signature.

Results

One hundred and fourteen miRNAs were differentially expressed between OSCC and normal oral epithelium, with the downregulation of miR-375 and upregulation of miR-31 as the most sign

SUBMITTER: Lajer CB 

PROVIDER: S-EPMC3048216 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature