Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.

ABSTRACT:

Background

The signaling cascades that direct the morphological differentiation of the vascular system during early embryogenesis are not well defined. Several signaling pathways, including Notch and VEGF signaling, are critical for the formation of the vasculature in the mouse. To further understand the role of Notch signaling during endothelial differentiation and the genes regulated by this pathway, both loss-of-function and gain-of-function approaches were analyzed in vivo.

Results

Conditional transgenic models were used to expand and ablate Notch signaling in the early embryonic endothelium. Embryos with activated Notch1 signaling in the vasculature displayed a variety of defects, and died soon after E10.5. Most notably, the extraembryonic vasculature of the yolk sac di

SUBMITTER: Copeland JN 

PROVIDER: S-EPMC3051915 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature