Association between polymorphism rs6983267 and gastric cancer risk in Chinese population.

ABSTRACT:

Aim

To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.

Methods

A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.

Results

The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio

SUBMITTER: Guo Y 

PROVIDER: S-EPMC3072642 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature