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ABSTRACT: Aim
To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.Methods
A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.Results
The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively).Conclusion
This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
SUBMITTER: Guo Y
PROVIDER: S-EPMC3072642 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Guo Yi Y Fang Jing J Liu Yan Y Sheng Hai-Hui HH Zhang Xiao-Yan XY Chai Hai-Na HN Jin Wei W Zhang Ke-Hao KH Yang Chang-Qing CQ Gao Heng-Jun HJ
World journal of gastroenterology 20110401 13
<h4>Aim</h4>To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.<h4>Methods</h4>A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association betw ...[more]