Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population.

ABSTRACT:

Aim

To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk.

Methods

We performed a hospital-based, case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals (304 gastric cancer patients and 304 age and sex matched cancer-free controls).

Results

The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups (P = 0.037). Compared with CC genotype carriers, subjects with the variant genotypes (GC + GG) had a 58% increased risk of gastric cancer (adjusted OR = 1.58, 95% CI: 1.11-2.20, P = 0.009). Moreover, a higher gastric cancer risk was especially evident in younger individuals aged < or =58 years, nonsmokers, a

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC2909559 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature