β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.

ABSTRACT:

Aim

Impaired heart rate (HR) response to exercise is associated with increased cardiovascular morbidity and mortality. We analyzed whether common variants (rs5443/C825T and rs5442/G814A) in the G-protein β3 subunit (GNB3) gene modulate interindividual variation in β-blocker responses with respect to HR.

Materials & methods

Among 1614 subjects (347 current β-blocker users) of a population-based study, HR during symptom-limited exercise testing was analyzed by multilevel linear regression models adjusted for potential confounders.

Results

In β-blocker users, but not in nonusers, HR was attenuated in rs5443 T allele carriers (TC/TT vs CC) with lower adjusted HR over the entire exercise period from rest to peak workload (3.5 bpm; 95% CI: 1.1-5.8; p < 0.01), and during rec

SUBMITTER: Dorr M 

PROVIDER: S-EPMC3074105 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature