Prediction of postoperative recurrence-free survival in non-small cell lung cancer by using an internationally validated gene expression model.

ABSTRACT:

Purpose

This study was performed to discover prognostic genomic markers associated with postoperative outcome of stage I to III non-small cell lung cancer (NSCLC) that are reproducible between geographically distant and demographically distinct patient populations.

Experimental design

American patients (n = 27) were stratified on the basis of recurrence and microarray profiling of their tumors was performed to derive a training set of 44 genes. A larger Korean patient validation cohort (n = 138) was also stratified by recurrence and screened for these genes. Four reproducible genes were identified and used to construct genomic and clinicogenomic Cox models for both cohorts.

Results

Four genomic markers, DBN1 (drebrin 1), CACNB3 (calcium channel beta 3), FLAD1 (PP591;

SUBMITTER: Mitra R 

PROVIDER: S-EPMC3086939 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature