DNA methylation epigenotypes in breast cancer molecular subtypes.

ABSTRACT:

Introduction

Identification of gene expression based breast cancer subtypes is considered as a critical means of prognostication. Genetic mutations along with epigenetic alterations contribute to gene expression changes occurring in breast cancer. So far, these epigenetic contributions to sporadic breast cancer subtypes have not been well characterized, and there is only a limited understanding of the epigenetic mechanisms affected in those particular breast cancer subtypes. The present study was undertaken to dissect the breast cancer methylome and deliver specific epigenotypes associated with particular breast cancer subtypes.

Methods

Using a microarray approach we analyzed DNA methylation in regulatory regions of 806 cancer related genes in 28 breast cancer paired samples

SUBMITTER: Bediaga NG 

PROVIDER: S-EPMC3096970 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature