Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus.

ABSTRACT:

Background

Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source of potential novel antibiotics to combat resistant bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). A promising antimicrobial peptide is ranalexin, which has potent activity against Gram-positive bacteria, and particularly S. aureus. Understanding mode of action is a key component of drug discovery and network biology approaches enable a global, integrated view of microbial physiology, including mechanisms of antibiotic killing. We developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles,

SUBMITTER: Overton IM 

PROVIDER: S-EPMC3123200 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature