Generation of bivalent chromatin domains during cell fate decisions.

ABSTRACT:

Background

In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell fate decisions. However, rather than representing an equivalently balanced epigenetic mark, the patterns and levels of histone modifications at bivalent genes can vary widely and the criteria for identifying this chromatin signature are poorly defined.

Results

Here, we initially show how chromatin status alters during lineage commitment and differentiation at a single well characterised bivalent locus. In addition we have determined how chromatin modifications at this locus change with gene

SUBMITTER: De Gobbi M 

PROVIDER: S-EPMC3131236 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature