Ontology highlight
ABSTRACT:
SUBMITTER: Collett ND
PROVIDER: S-EPMC3150458 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Collett Nathan D ND Carter Rich G RG
Organic letters 20110712 15
The synthesis of the C(15)-C(17)/N(1')-C(11') quinolizidine portion of himeradine A is disclosed. An intramolecular, heteroatom Michael addition was employed to establish the C(6') stereogenic center with high diastereoselectivity. The quinolizidine ring was constructed using microwave-induced cyclization at the N(1')-C(2') position. The C(17) stereogenic center was introduced through a diastereoselective Overman rearrangement. ...[more]