Assessment of hepatocyte growth factor in ovarian cancer mortality.

ABSTRACT:

Background

Invasive ovarian cancer is a significant cause of gynecologic cancer mortality.

Methods

We examined whether this mortality was associated with inherited variation in approximately 170 candidate genes/regions [993 single-nucleotide polymorphisms (SNPs)] in a multistage analysis based initially on 312 Mayo Clinic cases (172 deaths). Additional analyses used The Cancer Genome Atlas (TCGA; 127 cases, 62 deaths). For the most compelling gene, we immunostained Mayo Clinic tissue microarrays (TMA, 326 cases) and conducted consortium-based SNP replication analysis (2,560 cases, 1,046 deaths).

Results

The strongest initial mortality association was in HGF (hepatocyte growth factor) at rs1800793 (HR = 1.7, 95% CI = 1.3-2.2, P = 2.0 × 10(-5)) and with overall variatio

SUBMITTER: Goode EL 

PROVIDER: S-EPMC3153603 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature