Ontology highlight
ABSTRACT:
SUBMITTER: Zlotoff DA
PROVIDER: S-EPMC3158723 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Zlotoff Daniel A DA Zhang Shirley L SL De Obaldia Maria Elena ME Hess Paul R PR Todd Sarah P SP Logan Theodore D TD Bhandoola Avinash A
Blood 20110609 7
T-cell production depends on the recruitment of hematopoietic progenitors into the thymus. T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT), but the reasons for this delay are not well understood. Under normal physiologic conditions, thymic settling is selective and either CCR7 or CCR9 is required for progenitor access into the thymus. The mechanisms of early thymic reconstitution after BMT, however, are unknown. Here we report that thym ...[more]