Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
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ABSTRACT:
SUBMITTER: Gore AV
PROVIDER: S-EPMC3201658 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
Gore Aniket V AV Swift Matthew R MR Cha Young R YR Lo Brigid B McKinney Mary C MC Li Wenling W Castranova Daniel D Davis Andrew A Mukouyama Yoh-suke YS Weinstein Brant M BM
Development (Cambridge, England) 20111017 22
Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also ...[more]
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