Ontology highlight
ABSTRACT:
SUBMITTER: Zhao S
PROVIDER: S-EPMC3232675 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100201 5968
Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators. We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver ti ...[more]