Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.

ABSTRACT: Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predominant compared to uptake via hair cell basolateral membranes during perilymph infusion.

SUBMITTER: Li H 

PROVIDER: S-EPMC3240991 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature