Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3240991 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.
Li Hongzhe H Steyger Peter S PS
Scientific reports 20111116
Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predomi ...[more]
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