Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.

ABSTRACT:

Background

Recent studies have suggested that mast-cell activation and inflammation are important in obesity and diabetes. Plasma levels of mast cell proteases and the mast cell activator immunoglobulin E (IgE) may serve as novel inflammatory markers that associate with the risk of pre-diabetes and diabetes mellitus.

Methods and results

A total of 340 subjects 55 to 75 years of age were grouped according to the American Diabetes Association 2003 criteria of normal glucose tolerance, pre-diabetes, and diabetes mellitus. The Kruskal-Wallis test demonstrated significant differences in plasma IgE levels (P = 0.008) among groups with different glucose tolerance status. Linear regression analysis revealed significant correlations between plasma levels of chymase (P = 0.030) or IgE

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3241693 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature