Genes related to diabetes may be associated with pancreatic cancer in a population-based case-control study in Minnesota.

ABSTRACT:

Objectives

Type 2 diabetes is associated with increased pancreatic cancer risk; however, the nature of this relationship is not clear. We examined the link between 10 diabetes-related single-nucleotide polymorphisms and pancreatic cancer in a case-control study conducted in 1994 to 1998.

Methods

Cases (n = 162) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minn. Controls (n = 540) from the general population were frequency matched by age, sex, and race. Unconditional logistic regression provided odds ratios of pancreatic cancer and 95% confidence intervals (95% CIs).

Results

In a multivariate-adjusted model, a significant association was observed only for rs780094 in the glucokinase regulator (GCKR) gene: odds ratios for pancreatic cancer were 1.

SUBMITTER: Prizment AE 

PROVIDER: S-EPMC3241825 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature