Ontology highlight
ABSTRACT:
SUBMITTER: Zeve D
PROVIDER: S-EPMC3325026 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Cell metabolism 20120401 4
Adipose tissues provide circulating nutrients and hormones. We present in vivo mouse studies highlighting roles for Wnt signals in both aspects of metabolism. β-catenin activation in PPARγ-expressing fat progenitors (PBCA) decreased fat mass and induced fibrotic replacement of subcutaneous fat specifically. In spite of lipodystrophy, PBCA mice did not develop the expected diabetes and hepatosteatosis, but rather exhibited improved glucose metabolism and normal insulin sensitivity. Glucose uptake ...[more]