Differential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy.

ABSTRACT:

Background

The impact of different cytomegalovirus (HCMV) glycoprotein B (gB) genotypes on pathogenesis remains controversial.

Objectives

To investigate the effect of gB genotypes either as single infections or as part of multiple infections on the early kinetics of response to ganciclovir therapy.

Methods

Patients (n=239) enrolled in a study of intravenous ganciclovir or valganciclovir for the treatment of HCMV disease were analysed by a gB genotype specific PCR to quantify the amount of each gB genotype present at initiation of therapy (baseline, day 0) and at days 3, 7, 14 and 21 post therapy.

Results and conclusions

In all gB groups (individual gB genotype infections and mixed genotype infections) there was a biphasic decline in viral load after therapy. Th

SUBMITTER: Emery VC 

PROVIDER: S-EPMC3328767 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature