P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

ABSTRACT:

Background and purpose

We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity.

Methods

The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three

SUBMITTER: Kochunov P 

PROVIDER: S-EPMC3340599 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature