Evaluation of TRAF6 in a large multiancestral lupus cohort.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.

Methods

Fifteen single-nucleotide polymorphisms (SNPs) across TRAF6 were evaluated in 7,490 SLE patients and 6,780 control subjects from different ancestries. Population-based case-control association analyses and meta-analyses were performed. P values, false discovery rate q values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.

Results

Evidence of associatio

SUBMITTER: Namjou B 

PROVIDER: S-EPMC3380425 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature