Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate.

Methods

The in vitro antineoplastic effect and mechanism of action of Casiopeina III-ia (Cas III-ia), a copper compound, on rat malignant glioma C6 cells was investigated.

Results

Cas III-ia significantly inhibited cell proliferation, inducing autophagy and apoptosis, which correlated with the formation of autophagic vacuoles, overexpression of LC3, Beclin 1, Atg 7, Bax and Bid proteins. A decrease was detected in the mitochondrial membrane potential and in the activity of caspase 3 and 8, together with the generation of intracellu

SUBMITTER: Trejo-Solis C 

PROVIDER: S-EPMC3404907 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature