Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.

ABSTRACT:

Background

Transmitted drug resistance (TDR) is critical to managing HIV-1-infected individuals and being a public health concern. We report on TDR prevalence and include analyses of phylogenetic clustering of HIV-1 in a predominantly men who have sex with men cohort diagnosed during acute/recent HIV-1 infection in New York City.

Methods

Genotypic resistance testing was conducted on plasma samples of 600 individuals with acute/recent HIV-1 infection (1995-2010). Sequences were used for resistance and phylogenetic analyses. Demographic and clinical data were abstracted from medical records. TDR was defined according to International AIDS Society-USA and Stanford HIV database guidelines. Phylogenetic and other analyses were conducted using PAUP*4.0 and SAS, respectively.

Re

SUBMITTER: Castor D 

PROVIDER: S-EPMC3427460 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature