Relevance of PTEN loss in brain metastasis formation in breast cancer patients.

ABSTRACT:

Introduction

With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer.

Methods

Patterns of chromosomal aberrations in primary breast tumors and brain metastases were compared with array-comparative genetic hybridization (CGH). The most significant region was further characterized in more detail by microsatellite and gene-expression analysis, and finally, the possible target gene was screened for mutations.

Results

The array CGH results showed that brain metastases, in general, display similar chromosomal aberrations as do pr

SUBMITTER: Wikman H 

PROVIDER: S-EPMC3446383 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature