Ontology highlight
ABSTRACT:
SUBMITTER: Yu GY
PROVIDER: S-EPMC3483424 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20120906 2
Innate immunity controls pathogen replication and spread. Yet, certain pathogens, such as Hepatitis C Virus (HCV), escape immune elimination and establish persistent infections that promote chronic inflammation and related diseases. Whereas HCV regulatory proteins that attenuate antiviral responses are known, those that promote inflammation and liver injury remain to be identified. Here, we show that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse liver and human ...[more]