Ontology highlight
ABSTRACT:
SUBMITTER: Lopez MV
PROVIDER: S-EPMC3519982 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Lopez M Veronica MV Rivera Angel A AA Viale Diego L DL Benedetti Lorena L Cuneo Nicasio N Kimball Kristopher J KJ Wang Minghui M Douglas Joanne T JT Zhu Zeng B ZB Bravo Alicia I AI Gidekel Manuel M Alvarez Ronald D RD Curiel David T DT Podhajcer Osvaldo L OL
Molecular therapy : the journal of the American Society of Gene Therapy 20120904 12
Targeting the tumor stroma in addition to the malignant cell compartment is of paramount importance to achieve complete tumor regression. In this work, we modified a previously designed tumor stroma-targeted conditionally replicative adenovirus (CRAd) based on the SPARC promoter by introducing a mutated E1A unable to bind pRB and pseudotyped with a chimeric Ad5/3 fiber (Ad F512v1), and assessed its replication/lytic capacity in ovary cancer in vitro and in vivo. AdF512v1 was able to replicate in ...[more]