Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.

ABSTRACT:

Background

Standard clinical parameters cannot accurately differentiate indolent from aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki-67 improved prediction of prostate cancer death in a cohort of conservatively treated clinically localised prostate cancers diagnosed by transurethral resection of the prostate (TURP). Here, we present results in a more clinically relevant needle biopsy cohort.

Methods

Biopsy specimens were microarrayed. The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model.

Results

In univariate analysis (n=293), the hazard ratio (HR) (95% confidence interval

SUBMITTER: Fisher G 

PROVIDER: S-EPMC3566811 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature