Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix.

ABSTRACT:

Background

Experimental studies have established a causal connection between tumour hypoxia, hypoxia-associated proteome changes and downregulation of E-cadherin, the final common pathway of epithelial-to-mesenchymal transition (EMT). Our study aimed at elucidating the interrelationship of these processes in cancers of the uterine cervix in vivo.

Methods

Tumour oxygenation was assessed in 48 squamous cell carcinomas (SCC) of the uterine cervix using polarographic needle electrodes. The expression pattern of E-cadherin was investigated by immunohistochemistry and western blotting, and was compared with that of the hypoxia-inducible proteins glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX in biopsy specimens of the oxygenation measurement tracks.

Results

The

SUBMITTER: Mayer A 

PROVIDER: S-EPMC3566820 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature