Ischemic stroke is associated with the ABO locus: the EuroCLOT study.

ABSTRACT:

Objective

End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.

Methods

Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).

Results

Stage 1 identified 524 single nuc

SUBMITTER: Williams FM 

PROVIDER: S-EPMC3582024 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature