The -144C/A polymorphism in the promoter of HSP90beta is associated with multiple organ dysfunction scores.

ABSTRACT:

Introduction

Variations in genetic background are the leading cause of differential susceptibility to traumatic infection. Heat shock protein 90 (HSP90), a broadly distributed and conserved molecule, regulates inflammation under stressful and traumatic conditions. However, the relationships between HSP90 genetic polymorphisms, post-traumatic inflammatory responses and organ function remain unknown.

Methods

A total of 286 healthy volunteers and patients with severe trauma took part in a single nucleotide polymorphism (SNP)-based analysis of the HSP90beta gene and a clinical association analysis. HSP90beta and TNF-alpha levels were determined using quantitative PCR and western blot. The transcriptional activity of the HSP90beta promoter was assayed using the Dual-Luciferase Re

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3596273 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature