A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.

ABSTRACT:

Objectives

The aim of this study was to assess if genetic variation in the PACE4 (paired amino acid converting enzyme 4) gene Pcsk6 influences the risk for symptomatic knee osteoarthritis (OA).

Methods

Ten PCSK6 single nucleotide polymorphisms were tested for association in a discovery cohort of radiographic knee OA (n=156 asymptomatic and 600 symptomatic cases). Meta-analysis of the minor allele at rs900414 was performed in three additional independent cohorts (total n=674 asymptomatic and 2068 symptomatic). Pcsk6 knockout mice and wild-type C57BL/6 mice were compared in a battery of algesiometric assays, including hypersensitivity in response to intraplantar substance P, pain behaviours in response to intrathecal substance P and pain behaviour in the abdominal constriction

SUBMITTER: Malfait AM 

PROVIDER: S-EPMC3603144 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature