The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy.

ABSTRACT:

Context

A recent trial showed that 1:3 μg:μg liothyronine (L-T3) substitution for levothyroxine (L-T4) achieving near-identical TSH levels resulted in a significant decrease in weight and cholesterol levels with no appreciable changes in cardiovascular parameters, suggesting a differential peripheral response to the therapy.

Objective

We characterized the pituitary-thyroid axis in hypothyroid patients receiving equivalent doses of L-T3 or L-T4 by escalating-dose TRH stimulation test.

Design

A secondary analysis of a L-T3 vs L-T4 therapy trial was performed.

Setting

The study was conducted at the National Institutes of Health.

Patients

Thirteen patients were studied.

Interventions

Escalating-dose (5, 15, and 200 μg) TRH stimulation test on both tre

SUBMITTER: Yavuz S 

PROVIDER: S-EPMC3644597 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature