Synthetic analogs for evaluating the influence of N-H...S hydrogen bonds on the formation of thioester in acetyl coenzyme A synthase.

ABSTRACT: A series of square planar methylnickel(II) complexes, (dppe)Ni(Me)(SAr) (dppe = 1,2-bis(diphenylphosphino)ethane); 2. Ar = phenyl; 3. Ar = pentafluorophenyl; 4. Ar = o-pivaloylaminophenyl; 5. Ar = p-pivaloylaminophenyl; (depe)Ni(Me)(SAr), (depe = 1,2-bis(diethylphosphino)ethane); 7. Ar = phenyl; 8. Ar = pentafluorophenyl; 9. Ar = o-pivaloylaminophenyl; 10. Ar = p-pivaloylaminophenyl), were synthesized via the reaction of (dppe)NiMe(2) (1) and (depe)NiMe(2) (6) with either the corresponding thiol or disulfide. These complexes were characterized by various spectroscopic methods including (31)P NMR, (1)H NMR, (13)C NMR and infrared spectroscopies and in most cases by X-ray diffraction analyses. Solid state and solution measurements establish that 4 and 9 contain intramolecular N-H...S bonds.

SUBMITTER: Ariyananda PW 

PROVIDER: S-EPMC3650029 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature