Calcium absorption response to cholecalciferol supplementation in hemodialysis.

ABSTRACT:

Background and objectives

Recent understanding of extrarenal production of calcitriol has led to the use of more vitamin D supplementation in CKD populations. This paper reports the effect of cholecalciferol supplementation on calcium absorption.

Design, setting, participants, & measurements

Paired calcium absorption tests were done before and after 12-13 weeks of 20,000 IU weekly cholecalciferol supplementation in 30 participants with stage 5 CKD on hemodialysis. The study was conducted from April to December of 2011. Calcium absorption was tested with a standardized meal containing 300 mg calcium carbonate intrinsically labeled with (45)Ca; 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured.

Results

25-Hydroxyvitamin D rose from 14.2 ng/ml (11.5-18.5) at

SUBMITTER: Armas LA 

PROVIDER: S-EPMC3675848 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature