Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation.

ABSTRACT:

Background

Salmonella are able to modulate host cell functions facilitating both uptake and resistance to cellular host defence mechanisms. While interactions between bacterial modulators and cellular proteins have been the main focus of Salmonella research, relatively little is known about mammalian gene regulation in response to Salmonella infection. A major class of mammalian gene modulators consists of microRNAs. For our study we examined interactions of microRNAs and regulated mRNAs in mammalian intestinal Salmonella infections using a piglet model.

Methodology/principal findings

After performing microRNA as well as mRNA specific microarray analysis of ileal samples from Salmonella infected as well as control piglets, we integrated expression analysis with target predic

SUBMITTER: Hoeke L 

PROVIDER: S-EPMC3691122 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature