Evolution of pan-genomes of Escherichia coli, Shigella spp., and Salmonella enterica.

ABSTRACT: Multiple sequencing of genomes belonging to a bacterial species allows one to analyze and compare statistics and dynamics of the gene complements of species, their pan-genomes. Here, we analyzed multiple genomes of Escherichia coli, Shigella spp., and Salmonella enterica. We demonstrate that the distribution of the number of genomes harboring a gene is well approximated by a sum of two power functions, describing frequent genes (present in many strains) and rare genes (present in few strains). The virtual absence of Shigella-specific genes not present in E. coli genomes confirms previous observations that Shigella is not an independent genus. While the pan-genome size is increasing with each new strain, the number of genes present in a fixed fraction of strains stabilizes quickly. For inst

SUBMITTER: Gordienko EN 

PROVIDER: S-EPMC3697250 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature