Convergent molecular evolution of genomic cores in Salmonella enterica and Escherichia coli.

ABSTRACT: One of the strongest signals of adaptive molecular evolution of proteins is the occurrence of convergent hot spot mutations: repeated changes in the same amino acid positions. We performed a comparative genome-wide analysis of mutation-driven evolution of core (omnipresent) genes in 17 strains of Salmonella enterica subspecies I and 22 strains of Escherichia coli. More than 20% of core genes in both Salmonella and E. coli accumulated hot spot mutations, with a predominance of identical changes having recent evolutionary origin. There is a significant overlap in the functional categories of the adaptively evolving genes in both species, although mostly via separate molecular mechanisms. As a strong evidence of the link between adaptive mutations and virulence in Salmonella, two human-restri

SUBMITTER: Chattopadhyay S 

PROVIDER: S-EPMC3430314 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature