Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.

ABSTRACT: Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA varian

SUBMITTER: McLaren PJ 

PROVIDER: S-EPMC3723635 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature