The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials.
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ABSTRACT:
SUBMITTER: Aweda TA
PROVIDER: S-EPMC3733397 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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The use of <sup>111</sup>Ag as a tool for studying biological distribution of silver-based antimicrobials.
Aweda Tolulope A TA Ikotun Oluwatayo O Mastren Tara T Cannon Carolyn L CL Wright Brian B Youngs Wiley J WJ Cutler Cathy C Guthrie James J Lapi Suzanne E SE
MedChemComm 20130601 6
Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified <sup>111</sup>Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [<sup>111</sup>Ag]SCC1 and investigated in biodistribution studies. ...[more]
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